abstract：:Elevation of the DNA-unwinding helicase RECQL4, which participates in various DNA repair pathways, has been suggested to contribute to the pathogenicity of various human cancers, including gastric cancer. In this study, we addressed the prognostic and chemotherapeutic significance of RECQL4 in human gastric cancer, wh...

journal_title：Cancer research

authors： Mo D,Fang H,Niu K,Liu J,Wu M,Li S,Zhu T,Aleskandarany MA,Arora A,Lobo DN,Madhusudan S,Balajee AS,Chi Z,Zhao Y

更新日期：2016-05-15 00:00:00

abstract：:Despite descriptions of light-mediated therapy in ancient texts and the discovery of photodynamic therapy (PDT) in the early 1900s, the landmark article in 1978 in Cancer Research by Dougherty and his colleagues at the Roswell Park Cancer Institute remains rightly viewed as the starting point for clinical PDT in moder...

journal_title：Cancer research

authors： Cengel KA,Simone CB 2nd,Glatstein E

更新日期：2016-05-01 00:00:00

abstract：:The roles played by cholesterol in cancer development and the potential of therapeutically targeting cholesterol homeostasis is a controversial area in the cancer community. Several epidemiologic studies report an association between cancer and serum cholesterol levels or statin use, while others suggest that there is...

journal_title：Cancer research

authors： Kuzu OF,Noory MA,Robertson GP

更新日期：2016-04-15 00:00:00

abstract：:Hypoxia is a common feature of solid tumors. Prolyl hydroxylase enzymes (PHD1-3) are molecular oxygen sensors that regulate hypoxia-inducible factor activity, but their functions in metastatic disease remain unclear. Here, we assessed the significance of PHD enzymes during the metastatic spread of colorectal cancer. P...

journal_title：Cancer research

authors： Radhakrishnan P,Ruh N,Harnoss JM,Kiss J,Mollenhauer M,Scherr AL,Platzer LK,Schmidt T,Podar K,Opferman JT,Weitz J,Schulze-Bergkamen H,Koehler BC,Ulrich A,Schneider M

更新日期：2016-04-15 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of immature myeloid cells that expand in tumor-bearing hosts in response to soluble factors produced by tumor and stromal cells. MDSC expansion has been linked to loss of immune effector cell function and reduced efficacy of immune-based cancer therapie...

journal_title：Cancer research

authors： Stiff A,Trikha P,Wesolowski R,Kendra K,Hsu V,Uppati S,McMichael E,Duggan M,Campbell A,Keller K,Landi I,Zhong Y,Dubovsky J,Howard JH,Yu L,Harrington B,Old M,Reiff S,Mace T,Tridandapani S,Muthusamy N,Caligiuri MA

更新日期：2016-04-15 00:00:00

abstract：:The protein phosphatase 2 (PP2A) holoenzyme consists of a catalytic subunit, a scaffold subunit, and a regulatory subunit. Based on loss-of-function analysis using PP2A catalytic inhibitors or inhibition via tumor viral antigens, limited studies suggest that PP2A is a putative tumor suppressor. However, PP2A has also ...

journal_title：Cancer research

authors： Hein AL,Seshacharyulu P,Rachagani S,Sheinin YM,Ouellette MM,Ponnusamy MP,Mumby MC,Batra SK,Yan Y

更新日期：2016-04-15 00:00:00

abstract：:The importance of invasion in the complex process of metastasis, although now well established, has been studied with increasing molecular detail due to the development of robust in vitro experimental assays. In this issue of Cancer Research, we highlight a paper published by George Poste and colleagues that compared ...

journal_title：Cancer research

authors： Welch DR

更新日期：2016-04-01 00:00:00

abstract：:Kinase inhibitors are used widely to treat various cancers, but adaptive reprogramming of kinase cascades and activation of feedback loop mechanisms often contribute to therapeutic resistance. Determining comprehensive, accurate maps of kinase circuits may therefore help elucidate mechanisms of response and resistance...

journal_title：Cancer research

authors： Olow A,Chen Z,Niedner RH,Wolf DM,Yau C,Pankov A,Lee EP,Brown-Swigart L,van 't Veer LJ,Coppé JP

更新日期：2016-04-01 00:00:00

abstract：:The ability of cancer cells to evade apoptosis is dictated by a shift in the balance between proapoptotic and antiapoptotic gene expression programs. Monocyte chemotactic protein-induced protein 1 (MCPIP1) is a zinc-finger RNA binding protein with important roles in mediating inflammatory responses. Overexpression of ...

journal_title：Cancer research

authors： Lu W,Ning H,Gu L,Peng H,Wang Q,Hou R,Fu M,Hoft DF,Liu J

更新日期：2016-03-15 00:00:00

abstract：:Recombinant immunotoxins (RIT) have been highly successful in cancer therapy due, in part, to the high cancer-specific expression of cell surface antigens such as mesothelin, which is overexpressed in mesothelioma, ovarian, lung, breast, and pancreatic cancers, but is limited in normal cells. RG7787 is a clinically op...

journal_title：Cancer research

authors： Ali-Rahmani F,FitzGerald DJ,Martin S,Patel P,Prunotto M,Ormanoglu P,Thomas C,Pastan I

更新日期：2016-03-15 00:00:00

abstract：:Non-small cell lung cancer patients carrying oncogenic EGFR mutations initially respond to EGFR-targeted therapy, but later elicit minimal response due to dose-limiting toxicities and acquired resistance. EGF816 is a novel, irreversible mutant-selective EGFR inhibitor that specifically targets EGFR-activating mutation...

journal_title：Cancer research

authors： Jia Y,Juarez J,Li J,Manuia M,Niederst MJ,Tompkins C,Timple N,Vaillancourt MT,Pferdekamper AC,Lockerman EL,Li C,Anderson J,Costa C,Liao D,Murphy E,DiDonato M,Bursulaya B,Lelais G,Barretina J,McNeill M,Epple R,Mar

更新日期：2016-03-15 00:00:00

abstract：:Activation of the PI3K pathway occurs commonly in a wide variety of cancers. Experience with other successful targeted agents suggests that clinical resistance is likely to arise and may reduce the durability of clinical benefit. Here, we sought to understand mechanisms underlying resistance to PI3K inhibition in PTEN...

journal_title：Cancer research

authors： Nakanishi Y,Walter K,Spoerke JM,O'Brien C,Huw LY,Hampton GM,Lackner MR

更新日期：2016-03-01 00:00:00

abstract：:The potential to heighten the efficacy of antiangiogenic agents was explored in this study based on active targeting of tumor cells overexpressing the gonadotropin-releasing hormone receptor (GnRH-R). The rational design pursued focused on five analogues of a clinically established antiangiogenic compound (sunitinib),...

journal_title：Cancer research

authors： Argyros O,Karampelas T,Asvos X,Varela A,Sayyad N,Papakyriakou A,Davos CH,Tzakos AG,Fokas D,Tamvakopoulos C

更新日期：2016-03-01 00:00:00

abstract：:Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis that is associated with cell growth and tumor formation. Existing catalytic inhibitors of ODC have lacked efficacy in clinical testing or displayed unacceptable toxicity. In this study, we report the identification of a...

journal_title：Cancer research

authors： Kim DJ,Roh E,Lee MH,Oi N,Lim DY,Kim MO,Cho YY,Pugliese A,Shim JH,Chen H,Cho EJ,Kim JE,Kang SC,Paul S,Kang HE,Jung JW,Lee SY,Kim SH,Reddy K,Yeom YI,Bode AM,Dong Z

更新日期：2016-03-01 00:00:00

abstract：:Smokers develop metastatic prostate cancer more frequently than nonsmokers, suggesting that a tobacco-derived factor is driving metastatic progression. To identify smoking-induced alterations in human prostate cancer, we analyzed gene and protein expression patterns in tumors collected from current, past, and never sm...

journal_title：Cancer research

authors： Prueitt RL,Wallace TA,Glynn SA,Yi M,Tang W,Luo J,Dorsey TH,Stagliano KE,Gillespie JW,Hudson RS,Terunuma A,Shoe JL,Haines DC,Yfantis HG,Han M,Martin DN,Jordan SV,Borin JF,Naslund MJ,Alexander RB,Stephens RM,Loffr

更新日期：2016-03-01 00:00:00

abstract：:Methylation-mediated silencing of G0-G1 switch gene 2 (G0S2) has been detected in a variety of solid tumors, whereas G0S2 induction is associated with remissions in patients with acute promyelocytic leukemia, implying that G0S2 may possess tumor suppressor activity. In this study, we clearly demonstrate that G0S2 oppo...

journal_title：Cancer research

authors： Yim CY,Sekula DJ,Hever-Jardine MP,Liu X,Warzecha JM,Tam J,Freemantle SJ,Dmitrovsky E,Spinella MJ

更新日期：2016-03-01 00:00:00

abstract：:Oncogenic KRAS mutations occur frequently in lung adenocarcinoma. The signaling pathways activated by IL6 promote Kras-driven lung tumorigenesis, but the basis for this cooperation is uncertain. In this study, we used the gp130(F/F) (Il6st) knock-in mouse model to examine the pathogenic contribution of hyperactivation...

journal_title：Cancer research

authors： Brooks GD,McLeod L,Alhayyani S,Miller A,Russell PA,Ferlin W,Rose-John S,Ruwanpura S,Jenkins BJ

更新日期：2016-02-15 00:00:00

abstract：:Whole chromosomal instability (CIN), manifested as unequal chromosome distribution during cell division, is a distinguishing feature of most cancer types. CIN is generally considered to drive tumorigenesis, but a threshold level exists whereby further increases in CIN frequency in fact hinder tumor growth. While this ...

journal_title：Cancer research

authors： Lee HS,Lee NC,Kouprina N,Kim JH,Kagansky A,Bates S,Trepel JB,Pommier Y,Sackett D,Larionov V

更新日期：2016-02-15 00:00:00

abstract：:Consequences of the obesity epidemic on cancer morbidity and mortality are not fully appreciated. Obesity is a risk factor for many cancers, but the mechanisms by which it contributes to cancer development and patient outcome have yet to be fully elucidated. Here, we examined the effects of coculturing human-derived a...

journal_title：Cancer research

authors： Picon-Ruiz M,Pan C,Drews-Elger K,Jang K,Besser AH,Zhao D,Morata-Tarifa C,Kim M,Ince TA,Azzam DJ,Wander SA,Wang B,Ergonul B,Datar RH,Cote RJ,Howard GA,El-Ashry D,Torné-Poyatos P,Marchal JA,Slingerland JM

更新日期：2016-01-15 00:00:00

abstract：:The introduction of MAPK pathway inhibitors paved the road for significant advancements in the treatment of BRAF-mutant (BRAF(MUT)) melanoma. However, even BRAF/MEK inhibitor combination therapy has failed to offer a curative treatment option, most likely because these pathways constitute a codependent signaling netwo...

journal_title：Cancer research

authors： Herkert B,Kauffmann A,Mollé S,Schnell C,Ferrat T,Voshol H,Juengert J,Erasimus H,Marszalek G,Kazic-Legueux M,Billy E,Ruddy D,Stump M,Guthy D,Ristov M,Calkins K,Maira SM,Sellers WR,Hofmann F,Hall MN,Brachmann SM

更新日期：2016-01-15 00:00:00

abstract：:Genetic instability, a hallmark feature of human cancers including prostatic adenocarcinomas, is considered a driver of metastasis. Somatic copy number alterations (CNA) are found in most aggressive primary human prostate cancers, and the overall number of such changes is increased in metastases. Chromosome 10q23 dele...

journal_title：Cancer research

authors： Hubbard GK,Mutton LN,Khalili M,McMullin RP,Hicks JL,Bianchi-Frias D,Horn LA,Kulac I,Moubarek MS,Nelson PS,Yegnasubramanian S,De Marzo AM,Bieberich CJ

更新日期：2016-01-15 00:00:00

abstract：:Epidemiologic studies have shown that dietary sugar intake has a significant impact on the development of breast cancer. One proposed mechanism for how sugar impacts cancer development involves inflammation. In the current study, we investigated the impact of dietary sugar on mammary gland tumor development in multipl...

journal_title：Cancer research

authors： Jiang Y,Pan Y,Rhea PR,Tan L,Gagea M,Cohen L,Fischer SM,Yang P

更新日期：2016-01-01 00:00:00

abstract：:Modern cancer therapy/care involves the integration of basic, clinical, and population-based research professionals using state-of-the-art science to achieve the best possible patient outcomes. A well-integrated team of basic, clinical, and population science professionals and educators working with a fully engaged gr...

journal_title：Cancer research

authors： Welch DR,Antalis TM,Burnstein K,Vona-Davis L,Jensen RA,Nakshatri H,Riegel AT,Spitz DR,Watson DK,Weiner GJ,Cancer Biology Training Consortium.

更新日期：2015-12-15 00:00:00

abstract：:The treatment of glioblastoma (GBM) remains challenging in part due to the presence of stem-like tumor-propagating cells that are resistant to standard therapies consisting of radiation and temozolomide. Among the novel and targeted agents under evaluation for the treatment of GBM are BRAF/MAPK inhibitors, but their e...

journal_title：Cancer research

authors： Lerner RG,Grossauer S,Kadkhodaei B,Meyers I,Sidorov M,Koeck K,Hashizume R,Ozawa T,Phillips JJ,Berger MS,Nicolaides T,James CD,Petritsch CK

更新日期：2015-12-15 00:00:00

abstract：:KRAS-activating mutations drive human non-small cell lung cancer and initiate lung tumorigenesis in genetically engineered mouse (GEM) models. However, in a GEM model of KRAS(G12D)-induced lung cancer, tumors arise stochastically following a latency period, suggesting that additional events are required to promote ear...

journal_title：Cancer research

authors： Green S,Trejo CL,McMahon M

更新日期：2015-12-15 00:00:00

abstract：:Advances in cancer research and personalized medicine will require significant new bridging infrastructures, including more robust biorepositories that link human tissue to clinical phenotypes and outcomes. In order to meet that challenge, four cancer centers formed the Text Information Extraction System (TIES) Cancer...

journal_title：Cancer research

authors： Jacobson RS,Becich MJ,Bollag RJ,Chavan G,Corrigan J,Dhir R,Feldman MD,Gaudioso C,Legowski E,Maihle NJ,Mitchell K,Murphy M,Sakthivel M,Tseytlin E,Weaver J

更新日期：2015-12-15 00:00:00

abstract：:The histone acetyltransferases CBP/p300 are involved in recurrent leukemia-associated chromosomal translocations and are key regulators of cell growth. Therefore, efforts to generate inhibitors of CBP/p300 are of clinical value. We developed a specific and potent acetyl-lysine competitive protein-protein interaction i...

journal_title：Cancer research

authors： Picaud S,Fedorov O,Thanasopoulou A,Leonards K,Jones K,Meier J,Olzscha H,Monteiro O,Martin S,Philpott M,Tumber A,Filippakopoulos P,Yapp C,Wells C,Che KH,Bannister A,Robson S,Kumar U,Parr N,Lee K,Lugo D,Jeffrey P

更新日期：2015-12-01 00:00:00

abstract：:Malignant ascites is a common complication in the late stages of epithelial ovarian cancer (EOC) that greatly diminishes the quality of life of patients. Malignant ascites is a known consequence of vascular dysfunction, but current approved treatments are not effective in preventing fluid accumulation. In this study, ...

journal_title：Cancer research

authors： Moughon DL,He H,Schokrpur S,Jiang ZK,Yaqoob M,David J,Lin C,Iruela-Arispe ML,Dorigo O,Wu L

更新日期：2015-11-15 00:00:00

abstract：:The urokinase-type plasminogen activator receptor (uPAR) has a well-established role in cancer progression, but it has been little studied at earlier stages of cancer initiation. Here, we show that uPAR deficiency in the mouse dramatically reduces susceptibility to the classical two-stage protocol of inflammatory skin...

journal_title：Cancer research

authors： Mazzieri R,Pietrogrande G,Gerasi L,Gandelli A,Colombo P,Moi D,Brombin C,Ambrosi A,Danese S,Mignatti P,Blasi F,D'Alessio S

更新日期：2015-11-15 00:00:00

abstract：:Glioblastoma is an aggressive brain tumor characterized by an abnormal blood vasculature that is hyperpermeable. Here, we report a novel role for CD93 in regulating angiogenesis in this setting by modulating cell-cell and cell-matrix adhesion of endothelial cells. Tissue microarray analysis demonstrated that vascular ...

journal_title：Cancer research

authors： Langenkamp E,Zhang L,Lugano R,Huang H,Elhassan TE,Georganaki M,Bazzar W,Lööf J,Trendelenburg G,Essand M,Pontén F,Smits A,Dimberg A

更新日期：2015-11-01 00:00:00

abstract：:Tetracyclines, a class of antibiotics that target bacterial translation, are commonly used in research for inducible gene expression using Tet-ON/Tet-OFF systems. However, such tetracycline-inducible systems carry a risk. Given that mitochondria have a "bacterial" ancestry, these antibiotics also target mitochondrial ...

journal_title：Cancer research

authors： Chatzispyrou IA,Held NM,Mouchiroud L,Auwerx J,Houtkooper RH

更新日期：2015-11-01 00:00:00

abstract：:The Fas receptor ligand FasL regulates immune cell levels by inducing apoptosis of Fas receptor-positive cells. Here, we studied the impact of host FasL on tumor development in mice. Genetically targeting FasL in naïve mice increased myeloid cell populations, but, in marked contrast, it reduced the levels of myeloid-d...

journal_title：Cancer research

authors： Peyvandi S,Buart S,Samah B,Vétizou M,Zhang Y,Durrieu L,Polrot M,Chouaib S,Benihoud K,Louache F,Karray S

更新日期：2015-10-15 00:00:00

abstract：:Neuronal pentraxins (NPTX) and their corresponding receptors (NPTXR) have been studied as synapse-associated proteins in the nervous system, but their role in cancer is largely unknown. By applying a multidisciplinary, high-throughput proteomic approach, we have recently identified a peptide ligand motif for targeted ...

journal_title：Cancer research

authors： Bartolini A,Di Paolo D,Noghero A,Murgia D,Sementa AR,Cilli M,Pasqualini R,Arap W,Bussolino F,Ponzoni M,Pastorino F,Marchiò S

更新日期：2015-10-15 00:00:00

abstract：:Metastasis is the defining feature of advanced malignancy, yet remains challenging to study in laboratory environments. Here, we describe a high-throughput zebrafish system for comprehensive, in vivo assessment of metastatic biology. First, we generated several stable cell lines from melanomas of transgenic mitfa-BRAF...

journal_title：Cancer research

authors： Heilmann S,Ratnakumar K,Langdon E,Kansler E,Kim I,Campbell NR,Perry E,McMahon A,Kaufman C,van Rooijen E,Lee W,Iacobuzio-Donahue C,Hynes R,Zon L,Xavier J,White RM

更新日期：2015-10-15 00:00:00

abstract：:Natural killer (NK) immune cells mediate antibody-dependent cellular cytotoxicity (ADCC) by aggregating FcγRIIIA/CD16, contributing significantly to the therapeutic effect of CD20 monoclonal antibodies (mAb). In this study, we show that CD16 ligation on primary human NK cells by the anti-CD20 mAb rituximab or ofatumum...

journal_title：Cancer research

authors： Capuano C,Romanelli M,Pighi C,Cimino G,Rago A,Molfetta R,Paolini R,Santoni A,Galandrini R

更新日期：2015-10-01 00:00:00

abstract：:Thrombin-mediated proteolysis is a major determinant of metastasis, but is not universally important for primary tumor growth. Here, we report that colorectal adenocarcinoma represents one important exception whereby thrombin-mediated functions support both primary tumor growth and metastasis. In contrast with studies...

journal_title：Cancer research

authors： Adams GN,Rosenfeldt L,Frederick M,Miller W,Waltz D,Kombrinck K,McElhinney KE,Flick MJ,Monia BP,Revenko AS,Palumbo JS

更新日期：2015-10-01 00:00:00

abstract：:The Notch ligand delta-like 4 (Dll4) has been identified as a promising target in tumor angiogenesis in preclinical studies, and Dll4 inhibitors have recently entered clinical trials for solid tumors, including ovarian cancers. In this study, we report the development of REGN421 (enoticumab), a fully human IgG1 monocl...

journal_title：Cancer research

authors： Kuhnert F,Chen G,Coetzee S,Thambi N,Hickey C,Shan J,Kovalenko P,Noguera-Troise I,Smith E,Fairhurst J,Andreev J,Kirshner JR,Papadopoulos N,Thurston G

更新日期：2015-10-01 00:00:00

abstract：:Repurposing "old" drugs can facilitate rapid clinical translation but necessitates novel mechanistic insight. Warfarin, a vitamin K "antagonist" used clinically for the prevention of thrombosis for more than 50 years, has been shown to have anticancer effects. We hypothesized that the molecular mechanism underlying it...

journal_title：Cancer research

authors： Kirane A,Ludwig KF,Sorrelle N,Haaland G,Sandal T,Ranaweera R,Toombs JE,Wang M,Dineen SP,Micklem D,Dellinger MT,Lorens JB,Brekken RA

更新日期：2015-09-15 00:00:00

abstract：:Chemotherapy-induced peripheral neuropathy is a common, dose-limiting side effect of cancer treatment. This conference was the first of its kind to bring together a wide range of clinicians, researchers, and industry professionals to address the potential causes, preventions, and treatments for this drug toxicity. Int...

journal_title：Cancer research

authors： Smith JA,Benbow SJ

更新日期：2015-09-15 00:00:00

abstract：:Metastasis is the main reason for lung cancer-related mortality, but little is known about specific determinants of successful dissemination from primary tumors and metastasis initiation. Here, we show that CD133(+)/CXCR4(+) cancer-initiating cells (CIC) directly isolated from patient-derived xenografts (PDX) of non-s...

journal_title：Cancer research

authors： Bertolini G,D'Amico L,Moro M,Landoni E,Perego P,Miceli R,Gatti L,Andriani F,Wong D,Caserini R,Tortoreto M,Milione M,Ferracini R,Mariani L,Pastorino U,Roato I,Sozzi G,Roz L

更新日期：2015-09-01 00:00:00